AriZona x Marvel Super LXR Hero Hydration - Acai Blueberry - 16oz (Pack of 12) – Low Sugar Sports Drink, Perfect for Athletes, Vitamins and Natural Flavors - Thirst Quencher

Product Information

Beaven, S. W. et al. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 18, 106–117 (2013). Zhang, L. et al. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev. 25, 1262–1274 (2011). Characteristics of glucose and lipid metabolism and the interaction between gut microbiota and colonic mucosal immunity in pigs during cold exposure

Holzer, R. G. et al. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147, 173–184 (2011). Ghisletti, S. et al. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol. Cell 25, 57–70 (2007). Lo Sasso, G. et al. Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis. Cell Metab. 12, 187–193 (2010). Courtney, R. & Landreth, G. E. LXR regulation of brain cholesterol: from development to disease. Trends Endocrinol. Metab. 27, 404–414 (2016). Quinet, E. M. et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J. Lipid Res. 50, 2358–2370 (2009).Castrillo, A. et al. Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol. Cell 12, 805–816 (2003).

Rust, S. et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat. Genet. 22, 352–355 (1999). Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L. & Brown, M. S. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. J. Biol. Chem. 276, 4365–4372 (2001).Hong, C. & Tontonoz, P. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat. Rev. Drug Discov. 13, 433–444 (2014). Glass, C. K. & Rosenfeld, M. G. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14, 121–141 (2000). a, Quantification of western blot analysis (shown in Fig. 6b) to quantify relative SCD1 expression in Myc OE; Nras G12V; Cdkn2a ARF–/– cells upon 3 days of treatment with sorafenib, T0901317 or a combination thereof (quantified with ImageJ, only samples from the same blot were compared, values represent mean ± SD, n = 6 independent experiments, statistical significance was calculated using two-tailed Student´s t test, α-tubulin was used as a loading control). b, Quantification of western blot analysis (shown in Fig. 6c) to quantify relative SCD1 expression in Myc OE; Nras G12V; Cdkn2a ARF–/– cells upon treatment with T0901317 (2 d) and sorafenib (1-3 h) (quantified with ImageJ, only samples from the same blot were compared, values represent mean ± SD, n = 6 independent experiments, statistical significance was calculated using two-tailed Student´s t test, α-tubulin was used as a loading control). c, Representative western blot analysis of SCD1 in HLE cells upon treatment with T0901317 (2 d) and sorafenib (1-3 h) (cropped blot images, n = 3 independent experiments). α-tubulin was used as a loading control . d-f, Representative western blot analysis of SCD1 in Myc OE; Nras G12V; Cdkn2a ARF–/– cells upon treatment with T0901317 (2 d) and the DFG-out RAF inhibitors RAF-265 ( d) and RAF-709 ( e) or the DFG-in DFG-in RAF inhibitor SB590885 ( f) for 1 to 3 h (cropped blot images, n = 2 independent experiments). α-tubulin was used as a loading control. g, Representative western blot analysis of MEK and p-MEK1/2 (Ser217/221) in Myc OE; Nras G12V; Cdkn2a ARF–/– cells upon 6 h of treatment with sorafenib, BI-882370, dabrafenib or SB590885 (cropped blot images, n = 2 independent experiments). α-tubulin was used as a loading control. h, Representative western blot analysis of SCD1 in Myc OE; Nras G12V; Cdkn2a ARF–/–; Raf1 WT cells upon treatment with T0901317 (2 d) and sorafenib for 1 to 3 h (cropped blot images, n = 2 independent experiments). α-tubulin was used as a loading control. i, Representative western blot analysis of Raf-1 in Myc OE; Nras G12V; Cdkn2a ARF–/–;sh Raf1 or Myc OE; Nras G12V; Cdkn2a ARF–/–;shNC cells, 4 days upon treatment with doxycycline (cropped blot images, n = 2 independent experiments). j, Treatment of Myc OE; Nras G12V; Cdkn2a ARF–/– cells with carrier, T0901317, the MEK1/2 inhibitor PD0325901 or a combination thereof (quantification of viable cells by crystal violet staining, values represent mean ± SD, n = 3 independent experiments, statistical significance was calculated using two-tailed Student´s t test). Unprocessed images of the blots and numerical source data are provided as source data files. Hashidate-Yoshida, T. et al. Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. eLife 4, e06328 (2015). a, Analysing potential liver damage in C57BL/6 wildtype mice upon a 3-week T0901317/sorafenib treatment. b, Liver-to-body ratio of mice upon a 3-week treatment with T0901317/sorafenib or carrier (values represent mean ± SD, n = 3 mice per group, statistical significance was calculated using two-tailed Student´s t test). c, Representative pictures of murine livers upon a 3-week treatment with T0901317/sorafenib or carrier that were stained with H+E, Oil red O, Ki67, cleaved caspase 3, TUNEL and Sirius red ( n = 3 mice per group). TUNEL and cleaved caspase 3 positive control = Intraperitoneal injection of Jo2 antibody. Sirius red positive control = Bi-weekly intraperitoneal injections of CCl 4 for 6 weeks. Ki67 positive control = Myc OE; Nras G12V HCC. Scale bars, 100 µm. d, Analysing potential liver damage in C57BL/6 wildtype mice upon 6 months of T0901317/sorafenib treatment. e, Liver-to-body ratio of mice upon a 6-month treatment with T0901317/sorafenib or carrier (values represent mean ± SD, n = 6 mice per group, statistical significance was calculated using two-tailed Student´s t test). f, Representative pictures of murine livers upon a 6-month treatment with T0901317/sorafenib or carrier that were stained with H + E, Oil red O, Ki67, cleaved caspase 3, TUNEL and Sirius red ( n = 6 mice per group). Scale bars, 100 µm. g,h, Weight development of mice during 2 weeks ( g) or 6 months ( h) of treatment with T0901317/sorafenib or carrier (values represent mean ± SD, n = 3 (g) or 6 (h) mice per group, statistical significance was calculated using two-tailed Student´s t test). Numerical source data are provided as source data files.

Ito, A. et al. Cholesterol accumulation in CD11c(+) immune cells is a causal and targetable factor in autoimmune disease. Immunity 45, 1311–1326 (2016). Graf, G. A. et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J. Clin. Invest. 110, 659–669 (2002). Yu, L. et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110, 671–680 (2002). Ishibashi, S., Goldstein, J. L., Brown, M. S., Herz, J. & Burns, D. K. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93, 1885–1893 (1994). Kalaany, N. Y. et al. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 1, 231–244 (2005).Levin, N. et al. Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists. Arterioscler. Thromb. Vasc. Biol. 25, 135–142 (2005). Brown, M. S. & Goldstein, J. L. A receptor-mediated pathway for cholesterol homeostasis. Science 232, 34–47 (1986).

Holohan, C., Van, S. S., Longley, D. B. & Johnston, P. G. Cancer drug resistance: an evolving paradigm. Nat. Rev. Cancer 13, 714–726 (2013). Mendez, J. & Stillman, B. Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol. 20, 8602–8612 (2000). McCullough, K. D., Martindale, J. L., Klotz, L. O., Aw, T. Y. & Holbrook, N. J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21, 1249–1259 (2001).

Pencheva, N., Buss, C. G., Posada, J., Merghoub, T. & Tavazoie, S. F. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation. Cell 156, 986–1001 (2014). Seehawer, M. et al. Necroptosis microenvironment directs lineage commitment in liver cancer. Nature 562, 69–75 (2018). Yahagi, N. et al. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J. Biol. Chem. 274, 35840–35844 (1999). Raoul, J. L. et al. Systemic therapy for intermediate and advanced hepatocellular carcinoma: sorafenib and beyond. Cancer Treat. Rev. 68, 16–24 (2018). Evans, R. M. & Mangelsdorf, D. J. Nuclear receptors, RXR, and the big bang. Cell 157, 255–266 (2014).