Another central regulator of a coordinated immune-response is the TNFα cytokine [ 97]. Impairment of TNFα secretion massively influences the regulation of the immune-response. For that reason it is interesting that allicin inhibits the release of TNFα-dependent pro-inflammatory cytokines in intestinal epithelia [ 98]. This, however, reflects an effect of allicin on factors downstream of TNFα. Since TNFα is mainly secreted by macrophages [ 99], the effect of allicin on macrophages was examined with respect to how allicin influences the expression of TNFα itself. It is interesting that a stimulation of macrophages by lipopolysaccharide (LPS) after a pre-incubation in the presence of allicin enhances the activity of the TNFα promoter, suggesting a TNFα-triggering role for allicin in LPS-stimulated cells [ 100]. Furthermore, allicin inhibits phosphatase-activity, correlating with an enhanced phosphorylation of ERK1/2 ( ibid.), which is a central component of the signalling cascade transferring extracellular signals into intracellular signalling cascades. Furthermore, the release of Reactive Nitrogen Species (RNS) by LPS-stimulated macrophages was suppressed by allicin [ 100, 101].

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Research studies have demonstrated that allicin has antioxidant properties that can help significantly reduce oxidative stress. This means it may help protect against cellular damage, brain damage and many other age-related conditions. Allicin supplements are more accurately referred to as “garlic pills,” since they contain a number of active compounds. Allicin is responsible for the signature smell and taste of garlic.

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Several different types of garlic supplements are now available. Levels of organosulfur compounds that these supplements provide depends on how they were produced. Borlinghaus J, Albrecht F, Gruhlke MC, Nwachukwu ID, Slusarenko AJ. Allicin: chemistry and biological properties. Molecules. 2014;19(8):12591-12618. Published 2014 Aug 19. doi:10.3390/molecules190812591 Here’s where things get a little confusing. Garlic supplements do contain allinase and alliin (the precursors to allicin). If the garlic supplement is enterically coated, it can get to the small intestine (which has a more-neutral pH) without being damaged. The alliin can then be converted into allicin for the body to use. 10

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Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. 2013;71(5):282-99. doi: 10.1111/nure.12012. There are numerous compounds in garlic which are responsible for these health benefits, but researchers have pinpointed one in particular for its outstanding health benefits: allicin. Unfortunately though, getting the health benefits of allicin isn’t as easy as popping a garlic supplement. That’s disappointing, but you probably weren’t going to eat 45+ cloves of garlic per day anyway! 😉 Oh, and btw… Raw Garlic Might Wreak Havoc on Your Gut… For example, in this study on the antimalarial potential of allicin, rats (it is hard to find allicin studies with human subjects; most are on lab animals or in vitro) were given 5 to 8 mg of allicin per kilogram of body weight.

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In vitro studies have shown that allicin extract is capable of inducing cell death and inhibiting cancerous cell proliferation. It’s been found to fight against the invasion and metastasis of human colon carcinoma cells. FDA Disclaimer: These statements have not been approved by the FDA. Always consult your doctor before taking any herbal remedy or natural treatment! So, Should I Start Eating Raw Garlic to Get Allicin? Ajebli M, Eddouks M. Phytotherapy of Hypertension: An Updated Overview. Endocr Metab Immune Disord Drug Targets. 2020;20(6):812-839. doi:10.2174/1871530320666191227104648 Lawson L, Hunsaker S. Allicin bioavailability and bioequivalence from garlic supplements and garlic foods. Nutrients. 2018;10(7):812.