If your doctor has prescribed this medication, take as directed by your doctor. Your dosage is based on your medical condition, amount of sun exposure, diet, age, and response to treatment. Authorities disagree about how much vitamin D the body needs. In the United States, the Daily Value (DV) for vitamin D has been set at 800 International Units (IU). a b Vieth R (May 1999). "Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety". The American Journal of Clinical Nutrition. 69 (5): 842–56. doi: 10.1093/ajcn/69.5.842. PMID 10232622. a b "Office of Dietary Supplements - Vitamin D". ods.od.nih.gov. 11 February 2016. Archived from the original on 31 December 2016 . Retrieved 30 December 2016.

Some research suggests that obesity may be associated with low vitamin D levels. It’s also believed that vitamin D could influence body weight by regulating the growth of fat cells and altering the expression of certain genes and the levels of hormones that affect hunger, such as leptin [6] Karampela I, et al. Vitamin D and Obesity: Current Evidence and Controversies. Curr Obes Rep. 2021;10(2):162-180. . In general, vitamin D 3 is found in animal source foods, particularly fish, meat, offal, egg and dairy. [133] If you are taking the rapidly-dissolving tablets, dry your hands before handling the medication. Place each dose on the tongue, allow it to dissolve completely, and then swallow it with saliva or water. You do not need to take this medication with water. Very good! Vitamin D is essential to your overall health and making sure you get enough is paramount to your well-being. Before you get started, it is important to know that there are different types of vitamin D: vitamin D3 and vitamin D2.

Low levels of vitamin D are associated with two major forms of human inflammatory bowel disease: Crohn's disease and ulcerative colitis. [89] Deficiencies in vitamin D have been linked to the severity of the case of inflammatory bowl disease, however, whether vitamin D deficiency causes inflammatory bowl disease or is a symptom of the disease is not clear. [90]

Your skin is your largest organ and vitamin D is critical to its health. The active form of Vitamin D (calcitriol) helps with skin repair and growth. Vitamin D3 is the precursor to Calcitriol. As you get older your body loses the ability to produce D3 which leads to a weaker immune system and weaker skin. 3) Healthy MusclesVitamin D toxicity is treated by discontinuing vitamin D supplementation and restricting calcium intake. Kidney damage may be irreversible. Exposure to sunlight for extended periods of time does not normally cause vitamin D toxicity. The concentrations of vitamin D precursors produced in the skin reach an equilibrium, and any further vitamin D produced is degraded. [158] Biosynthesis [ edit ] Colecalciferol comes as chewable, dissolvable (soluble) and melt-in-the-mouth (orodispersible) tablets, capsules, a syrup, and oral drops. Rodents are somewhat more susceptible to high doses than other species, and cholecalciferol has been used in poison bait for the control of these pests. [44] [16] The percentage of the population taking over 1000 IU/day, as well as the percentage taking over 4000 IU/day, have both increased since 1999, according to trend analysis. [165]

The main symptoms of vitamin D overdose are hypercalcemia including anorexia, nausea, and vomiting. These may be followed by polyuria, polydipsia, weakness, insomnia, nervousness, pruritus and ultimately kidney failure. Furthermore, proteinuria, urinary casts, azotemia, and metastatic calcification (especially in the kidneys) may develop. [157] Other symptoms of vitamin D toxicity include intellectual disability in young children, abnormal bone growth and formation, diarrhea, irritability, weight loss, and severe depression. [24] [167] A study published in 2017 assessed the prevalence of high daily intake levels of supplemental vitamin D among adults ages 20+ in the United States, based on publicly available NHANES data from 1999 through 2014. Its data shows the following: a b "Aviticol 1 000 IU Capsules - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. Archived from the original on 30 December 2016 . Retrieved 29 December 2016. Cholecalciferol is made in the skin following UVB light exposure. [2] It is converted in the liver to calcifediol (25-hydroxyvitamin D) which is then converted in the kidney to calcitriol (1,25-dihydroxyvitamin D). [2] One of its actions is to increase calcium uptake by the intestines. [3] It is found in food such as some fish, beef liver, eggs, and cheese. [4] [5] Plants, cow milk, fruit juice, yogurt, and margarine also may have cholecalciferol added to them in some countries, including the United States. [4] [5]Because Vitamin D and calcium are related too much Vitamin D can lead to Calcium issues. These issues include, Hypercalcemia, Kidney Stones and Kidney damage. Keeping a healthy store of vitamin D gives added protection to such diseases as cancer, multiple sclerosis, and type 1 diabetes. Hydroxylation in the endoplasmic reticulum of liver hepatocytes of cholecalciferol to calcifediol (25-hydroxycholecalciferol) by 25-hydroxylase is loosely regulated, if at all, and blood levels of this molecule largely reflect the amount of cholecalciferol produced in the skin combined with any vitamin D 2 or D 3 ingested.

a b c d e f g Norman AW (August 2008). "From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health". The American Journal of Clinical Nutrition. 88 (2): 491S–499S. doi: 10.1093/ajcn/88.2.491S. PMID 18689389. Vitamin D supplementation in low doses (400 to 1000 IU/day) may slightly decrease the overall risk of acute respiratory tract infections. [86] The benefits were found in young children and adolescents (ages 1 up to 16 years) and were not confirmed with higher doses (>1000 IU per day or more). [86] Vitamin D supplementation substantially reduces the rate of moderate or severe exacerbations of COPD in people with baseline 25(OH)D levels under 25nmol/L, but not in those with less severe deficiency. [87] Asthma [ edit ] Vitamin D is very similar to calcitriol. Do not use medications containing calcitriol while using vitamin D.So it may not be a silver bullet for weight loss—but it likely helps to reduce fat. It would seem likely that overweight and Vitamin D deficient people would benefit more. How to Get Vitamin D3 Sunlight Australia and New Zealand published nutrient reference values including guidelines for dietary vitamin D intake in 2006. [114] About a third of Australians have vitamin D deficiency. [125] [126] European Union [ edit ] Cholecalciferol is very sensitive to UV radiation and will rapidly, but reversibly, break down to form supra-sterols, which can further irreversibly convert to ergosterol. [ citation needed] Pesticide [ edit ]