Combined deficits in audiovisual processing may then contribute to delays in language acquisition and speech comprehension during social interactions or school settings. The consumption of metal ores shows a more pronounced development obviously determined by the financial and economic crisis and by the recent COVID-19 recession. The expression of BDNF promotes GABAergic maturation, and manipulation of BDNF levels alters the timing of the ocular dominance critical period [ 77]. In support of inhibitory disruption, studies on autistic patients demonstrate broad alterations in the GABAergic system. In light of these findings, it is interesting to note that at least nine different mouse models of autism share a common disruption of PV-cells [ 58, 59].

The consumption of non-metallic minerals varied most across countries from around 2 tonnes per capita to around 29 tonnes per capita.The 103 third parties who use cookies on this service do so for their purposes of displaying and measuring personalized ads, generating audience insights, and developing and improving products.

Shank-3, the causal gene for 22q13 deletion syndrome, has also been found to be disrupted in autism [ 108, 111– 113]. Deficits in multisensory integration (MSI) fit with a popular theory of the autistic brain, in which there is excessive local connectivity within one brain region but long-range hyperconnectivity between brain regions [ 19, 42, 43].

Since getting more into sustainability and trying to live a more eco-friendly lifestyle I have tried a few alternatives. It is interesting to consider a model in which defects in the development of primary sensory abilities are the original problem, which then results in a cascading effect on higher integrative areas of the brain [ 20]. Reactivation of endogenous MeCP2, BDNF overexpression, and pharmacological and environmental interventions can rescue some aspects of Rett-like pathology [ 196]. In addition, cortical projection neurons exhibited increased dendritic spine densities, providing structural evidence for changes in connectivity in autism [ 133].